Hattiesburg quarterback Jarod Conner threw for three touchdowns and ran for three more as the Tigers topped Gautier 56-13 Friday night.
Gautier showed some life early, cutting the Hattiesburg lead to 7-6 on a 10-yard touchdown run by Kameron Kincaid, but that was as close as the Gators would get.
Kincaid completed 7 of 16 passes for 121 yards and a touchdown.
Conner completed 9 of 16 passes for 194 yards and three touchdowns and ran 14 times for 95 yards and three scores.
Gautier (1-4, 0-1) will host Long Beach in its second region contest.
Hattiesburg improved to 5-0 and 1-0.