St. Stanislaus fell behind at St. Paul early on Friday night and never could recover, falling 35-12.
Jake Greer completed 12 of 20 passes for 155 yards with a 4-yard touchdown to Harrison Brewer, who finished with five catches for 60 yards.
Greer's younger brother, Pat, completed his lone pass for a 47-yard touchdown to Jackson Thriffley.
Thomas Williams led SSC (1-1) with five receptions for 93 yards.
St. Stanislaus returns to action next week with a road contest at St. Martin.