The Golden Eagles watched their ninth inning lead vanish in front of a rowdy, 5,211-person crowd at Pete Taylor Park.
LSU used two home runs to force extra innings and walked it off in the bottom of the 10th to capture a 7-6 victory.
Here are photos from the NCAA regional in Hattiesburg. Southern Miss plays Kennesaw State on Sunday and could face LSU again on Monday night if they win.
Southern Miss pitches in the 7th inning against LSU during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Southern Miss pitcher Garrett Ramsey prepares to throw a pitch against LSU in the bottom of the ninth in an attempt to win Game Four of NCAA Regionals against Southern Miss at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Carson Paetow runs the bases after hitting a home run against LSU during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Hurston Waldrep celebrates after striking out an LSU player during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Christopher Sargent celebrates after scoring a home ruin during Game Four of NCAA Regionals against LSU at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Hurston Waldrep throws a pitch against LSU during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
LSU outfielder Josh Pearson catches a ball during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
LSU pitcher Ty Floyd throws a pitch against Southern Miss during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Hurston Waldrep throws a pitch against LSU during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Fans shield their eyes to the sun during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Christopher Sargent celebrates after scoring a home ruin during Game Four of NCAA Regionals against LSU at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
A Southern Miss outfielder tries to make a catch as the ball goes out of bounds during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
LSU pitcher Ty Floyd reacts after throwing a pitch against Southern Miss during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
LSU steps up to bat during game four of the NCAA Regionals Tournament in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Hurston Waldrep throws a pitch against LSU during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
Southern Miss celebrates after scoring a run against LSU during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
LSU fans cheer during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com
LSU fans cheer during Game Four of NCAA Regionals at Pete Taylor Park in Hattiesburg on Saturday, June 4, 2022. Hannah Ruhoff hruhoff@sunherald.com