Motorists traveling westbound on Interstate 10 toward Biloxi are advised to take an alternate route if possible before reaching Exit 38.
Two left westbound lanes are blocked due to 2 minor crashes, Biloxi police said.
The area is just before the Mississippi 605/Lorraine Road exit.
Both wrecks are being cleared from the roadway, police said.
The lanes are likely to be cleared for travel by 1:35 p.m., an MDOT alert said.