Westbound travelers on Interstate 10 experienced delays for about an hour Monday just past Exit 28, the exit to Long Beach and County Farm Road.
The crash occurred about 10:30 a.m., according to the Mississippi Department of Transportation. All lanes re-opened just before 11:30 a.m.
A white Chevrolet Silverado rear-ended a silver Toyota Sienna, Mississippi Highway Patrol spokesman Chase Elkins said.
Minor injuries were reported from people in both vehicles, he said.
Traffic cameras show it happened in an area where a third lane ends, with only two lanes of travel.
Traffic was allowed to pass on the right shoulder of the highway until one lane could be re-opened, Harrison County Fire Chief Pat Sullivan said.
A second crash occurred in the area, which further congested traffic, Elkins said. A vehicle overturned but no injuries were reported.