Southern Miss fell to Rice 76-74 in overtime Thursday at Reed Green Coliseum.
The Golden Eagles (7-19, 4-11) led Rice (12-16, 7-8) 30-28 at halftime, but the visitors rallied to force overtime.
Kourtlin Jackson led USM with 31 points on 9 of 18 shooting from the field and 6 of 13 from 3-point land. Khari Price and Quinton Campbell chipped in 12 and 14 points respectively.
Rice was led in scoring by Marcus Evans' 32-point performance. Connor Cashaw scored 13 and Egor Koulechov scored 11 points.