One person was injured in an early morning wreck near County Farm Road, just south Interstate 10.
Harrison County Fire Chief Pat Sullivan said a car hit an 18-wheeler around 5:30 a.m.
He said the driver of the car had to be extricated by units from the Harrison County Fire Service, Lizana Fire, CRTC and Pass Christian Fire. AMR took the driver to Garden Park Hospital.
The road was closed for about 30 minutes.
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The Harrison County Sheriff's Office is investigating the cause of the accident.